From ILLINOIS/ST. LOUIS: U.S. 40/61: WEST across the Boone Bridge, Exit at Hwy 94. Turn LEFT (South), travel 8 miles to Hwy F. Turn RIGHT, The Historic Daniel Boone Home is 5 miles on the LEFT.
From WESTBOUND 1-70: SOUTH (Left) on Hwy 94 (First Capitol Drive) approximately 20 miles to Hwy F. Turn RIGHT, travel 5 miles, The Historic Daniel Boone Home is on the LEFT.
From EASTBOUND 1-70: Take the Foristell Exit (Hwy T). Travel to the Hwy T/Hwy D intersection, continue traveling straight on Hwy D. Continue into the town of New Melle, turn RIGHT on Hwy F, The Historic Daniel Boone Home is 5 miles on the RIGHT.
From WASHINGTON, MO I-44 EAST: NORTH on Hwy 47, turn RIGHT at Hwy 94. Travel through the town of Dutzow to the intersection of 94 and TT. Continue straight on TT until Hwy T. Turn RIGHT on Hwy T. Follow T 1/2 miles to Cappelln Osage Road (to village of Femme Osage). Turn LEFT and follow Cappelln Osage Road to Femme Osage Creek Road to Highway F, turn RIGHT and travel 1 mile. Te Historic Daniel Boone Home is on the right.